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Abstract
The rectal intestinal content and large intestinal mucosa have been examined by transmission electron microscopy and immunohistochemistry in 320 patients of whom 105 have ulcerative colitis. There is a highly significant increase in the number of yeast cells with an intact cell wall in the rectal intestinal content of patients with ulcerative colitis (even those 25 newly diagnosed and untreated patients). There is a highly significant increase in the number of yeast cells lacking a cell wall in the rectal intestinal content of patients not suffering from ulcerative colitis. The persistence of the yeast cell wall is associated with ulcerative colitis. The role of the yeast cell wall, mannan, macrophage mannose receptors and mannanase in ulcerative colitis is explored.
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