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Abstract
Immunohistochemical studies on resin embedded gastric biopsies have been performed to investigate the changes to eosinophils in the gastric mucosa as a result of Helicobacter pylori infection. There is an increase in the number of eosinophils and an increased activation of eosinophils as measured by the amount of major basic protein in patients with Helicobacter pylori infection. Helicobacter pylori infection is associated with upregulation of IL-4, IL-5, TNFα, ICAM-1, Eotaxin and IgE. This upregulation would result in the greater release of eosinophil progenitor cells and an increased recruitment of eosinophils into the tissues. The implications of these changes are discussed.
Keywords: Stomach, eosinophils, cytokines, Helicobacter pylori.
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