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Abstract
Immunohistochemistry and ultrastructure have been used to examine changes in gastric mucosal mast cells associated with Helicobacter pylori infection. There is significant activation of these mast cells. This activation, together with the exposure of the epithelium to urea, can result in the zona occludens of the surface epithelium at the gastric lumen becoming ‘leaky’ for antigenic molecules from the gastric lumen. The extracellular exposure of these epithelial cells in the intercellular space to antigen results in the loss of the superficial epithelium causing the development of gastric erosions.
Keywords: Stomach, mast cells, Helicobacter pylori, gastric erosions.
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