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Abstract
Gastric biopsies have been examined by immunohistochemistry and by electron microscopy in normal patients and patients with Helicobacter pylori infection. Epithelial necrosis of gastric glands resulting in the shedding of these necrosing epithelial cells is found in patients with Helicobacter pylori infection.
There is upregulation of interleukin 2, interleukin 4, interferon gamma and tumour necrosis factor alpha in Helicobacter pylori infection. Evidence is presented that these upregulated cytokines lead to the development of the cytocidal lymphocytes responsible for inducing the epithelial necrosis. The necrosing chief cells with their secretions, being shed into the gastric gland lumen would constitute holocrine secretion.
Keywords: Stomach, epithelial necrosis, Helicobacter pylori, cytotoxic lymphocyte, cytokines, holocrine secretion.
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